Preparation and Characterization of Cationic PLA-PEG Nanoparticles for Delivery of Plasmid DNA
نویسندگان
چکیده
منابع مشابه
Preparation and Characterization of Cationic PLA-PEG Nanoparticles for Delivery of Plasmid DNA
The purpose of the present work was to formulate and evaluate cationic poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) nanoparticles as novel non-viral gene delivery nano-device. Cationic PLA-PEG nanoparticles were prepared by nanoprecipitation method. The gene loaded nanoparticles were obtained by incubating the report gene pEGFP with cationic PLA-PEG nanoparticles. The physicochemical prope...
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Tri-block poly (lactide) poly(ethylene glycol) poly(lactide) (PLA–PEG–PLA) copolymers are among the most attractive nano-carriers for gene delivery into mammalian cells, due to their biocompatibility and biodegradability properties. However, the low efficiency of the gene delivery by these copolymers is an obstacle to gene therapy. Here, we have investigated nanoparticles formulated using the p...
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ژورنال
عنوان ژورنال: Nanoscale Research Letters
سال: 2009
ISSN: 1931-7573,1556-276X
DOI: 10.1007/s11671-009-9345-3